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3640 Recent studies suggest that the mechanisms underlying quinolone resistance are primarily mediated by chromosomal mutations and/or uptake of plasmid genes that alter topoisomerase targets, modify quinolones, and/or reduce uptake or increase efflux of accumulated drugs

But when it does, patients might notice their skin and eyes getting a bit yellow, as discussed in this article viewable on Google Scholar

Two key outer membrane proteins, blood group antigen-binding adhesion (BabA) and salivary acid-binding adhesion (SabA), play significant roles (Malfertheiner et al., 2023)

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